Amy Rose Locane (born December 19, 1971) is an American television and film actress known for her role in John Waters' 1990 musical comedy Cry-Baby. In 1992, Locane played the role of Sandy Harling in the first season of the prime time soap opera Melrose Place. She also played a role in the 1992 film School Ties as the love interest of Matt Damon and Brendan Fraser.
Locane was born in Trenton, New Jersey, and graduated from Villa Victoria Academy. By age 12, she had performed in more than 60 commercials before being cast as a series regular on the sitcom Spencer (1984).
In 1989, Locane made her big screen debut in the independent teen drama film Lost Angels starring opposite Adam Horowitz. The following year, Locane had a lead role opposite Johnny Depp as Allison Vernon-Williams in John Waters' romantic comedy film Cry-Baby. The film did not achieve high audience numbers in its initial release, but has subsequently become a cult classic. She also twice played the girlfriend of Brendan Fraser, in the films School Ties (1992) and Airheads (1994).