Darlene Cates (born Rita Darlene Guthrie; December 13, 1947 – March 26, 2017) was an American actress. She was best known for her role in the 1993 film What's Eating Gilbert Grape, in which she played the title character's housebound mother.
Author and screenwriter Peter Hedges saw a tape of Cates on a 1992 episode of Sally entitled "Too Heavy to Leave Their House". On the show, she discussed her battle with obesity and how it had affected her life. In 1986, pelvic infections caused by her excess weight kept her bedridden for two years, during which she gained an additional 149 pounds. Hedges offered her the role of a morbidly obese mother in the 1993 film What's Eating Gilbert Grape, which she accepted. Television roles followed on the shows Picket Fences in 1994 and Touched by an Angel in 1996. She had a small role in the 2001 film Wolf Girl. Producer J. Miles Dale flew a small crew and the film's stars from Romania to Texas to shoot their scenes with Cates.