Brandon Jerome Mebane (born January 15, 1985) is an American football defensive tackle for the Los Angeles Chargers of the National Football League (NFL). He attended Crenshaw High School in Los Angeles. He played college football at California. He was drafted by the Seattle Seahawks in the third round of the 2007 NFL Draft.
Mebane played four seasons at California, recording 109 tackles, 25.5 tackles for a loss, 14.5 sacks, 1 forced fumble, and 1 fumble recovery.
Mebane was selected by the Seattle Seahawks in the 3rd round, 85th overall of the 2007 NFL Draft, and on July 24, he signed a four-year contract. In his rookie season, he played all 16 games and recorded 29 tackles including 2 sacks. 2008 was a promising year for Mebane as he again played all 16 games and recorded 39 tackles, 5.5 sacks, and 2 forced fumbles. With the departure of Rocky Bernard, Mebane was expected to make a big impact for the Seahawks in 2009 in which he started 15 games and recorded 49 tackles and 1.5 sacks. For the 2010 season Mebane started the first four games but suffered a calf injury and was forced to sit out the next 4 games. In the first 4 games he had 8 tackles and 1 sack.