Orestis-Spyridon Karnezis (Greek: Ορέστης-Σπυρίδων Καρνέζης; born 11 July 1985) is a Greek footballer who plays as a goalkeeper for Italian club Napoli and the Greek national team.
Born in Athens, but grew up in Corfu, Karnezis started his professional football career at Panathinaikos in 2007. He made only a few appearances for the club until the 2011–12 season, when he got more chances and impressed. After a few months, his coach, Jesualdo Ferreira, made him the regular goalkeeper of Panathinaikos. He had great performances and saved his team at crucial moments. Reports from Greece indicate that Karnezis was the subject of transfer speculation, as the Greek international attracted suitors from around Europe, following a solid campaign in the Superleague Greece 2012–13 season. Reports from Greece indicated that Udinese Calcio emerged as front-runners to sign Karnezis, after the Italian club reportedly offered €800,000 to bring Karnezis to the Serie A that summer. Karnezis took over as Panathinaikos' number one choice in goal that season and played admirably for the Athens giants. Karnezis' exploits for the Trifylli earned him consistent call-ups to the Greek national football team.