Melissa Ponzio (born August 3, 1972) is an American actress, best known for her roles as Melissa McCall on Teen Wolf and Karen on The Walking Dead. Most recently, Ponzio has starred in Chicago Fire as Donna Robbins.
Ponzio was born in New York City and graduated from Georgia State University. As of the late 1990s, Ponzio began appearing in supporting guest roles on television series, including Dawson's Creek, One Tree Hill, Surface, Drop Dead Diva, CSI: Crime Scene Investigation, The Gates, NCIS, The Following and Banshee. She also appeared in films The Greenskeeper (2002), Road Trip: Beer Pong (2009), Life as We Know It (2010) and Upside (2010).
Ponzio is known for her recurring roles as Angie on the Lifetime Television drama series Army Wives (2007–2009), and as Melissa McCall in the MTV teen drama Teen Wolf (2011–2017). In 2013, she had a recurring role as Karen in the AMC drama series The Walking Dead.