Mario Alberto Santana (born 23 December 1981) is an Argentine footballer who last played as a winger for Italian club Pro Patria.
He started his career for Argentinian team San Lorenzo. After his contract with San Lorenzo expired, he decided to try his luck in European football, moving to Italy in January 2002 for Serie A team Venezia, then relegated at the end of the season. He then followed his chairman Maurizio Zamparini to Serie B team Palermo, where he showed high qualities in his role.
In 2003, he was then loaned to Serie A side A.C. ChievoVerona (along with Stefano Morrone with Eugenio Corini moved to opposite direction), becoming one of the most interesting wingers in the Italian top division, and being first capped for the Argentina national football team in a friendly match against Japan on 18 August 2004. He then came back to Palermo, that was just promoted in Serie A at the time, for the following season.