Maggie Celine Louise De Block (born 28 April 1962) is a Belgian politician and member of the Flemish liberal party Open Vld. In 2013 and 2014, she was voted the most popular politician in Flanders. In February 2015, she was voted the most popular politician in Belgium, being the most popular in all three regions. She held the portfolio of Minister of Social Affairs and Health in the Michel Government, but following a reshuffle on 9 December 2018 to prevent the government's collapse, she was assigned to the post of Secretary of State for Asylum and Migration.
De Block was born in Merchtem. She studied medicine at the Vrije Universiteit Brussel (VUB) after which she became a general practitioner for 25 years. Her brother, Eddie De Block, is the mayor of Merchtem.
From 1999 to 2011 Maggie De Block was a Member of the Belgian Chamber of Representatives for the electoral district Brussels-Halle-Vilvoorde.