Karen Lynne Valentine (born May 25, 1947) is an American actress. She is best known for her role as the idealistic schoolteacher Alice Johnson in the ABC comedy drama series Room 222 from 1969 to 1974, for which she won Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series in 1970, and received a Golden Globe Award nomination in 1971. She later went to star in her own short-lived sitcom Karen (1975), and played leading roles in films Hot Lead and Cold Feet (1978) and The North Avenue Irregulars (1979).
Valentine grew up in Sebastopol, California and won a spot representing California at the Miss Teenage America pageant, where she was awarded the Talent Award. Valentine was Miss Sonoma County and Top 10 at Miss California, state finals to Miss America. When Ed Sullivan saw her act (where she would comically dance in a flamboyant costume while lip-synching to Eydie Gormé's "Blame it on the Bossa Nova"), he was quoted as saying, "I want that girl on my show."