Jaime Manuel Penedo Cano (born 26 September 1981) is a Panamanian former professional footballer who played as a goalkeeper for various teams such as: Osasuna B, CSD Municipal, LA Galaxy, Deportivo Saprissa or Dinamo București, among others, but also for the Panama national team, being the goalkeeper of the first squad of Panama that ever played in a World Cup. Penedo announced his retirement on 24 January 2019.
Penedo began his career with Estudiantes de Panamá F.C. and made his first team debut in 2000. He also played in Panamá for Plaza Amador and Árabe Unido. In his first season with Árabe Unido, Penedo helped the club to the apertura and clausura titles. In summer 2005 he joined Italian club Cagliari but did not make any first team appearances. The following season, he moved to Spain to play for Osasuna B in Segunda División B. After one season in Spain, Penedo returned to Central America, signing in Guatemala for Municipal. During his time with Municipal Penedo claimed four league titles.