Guillaume Depardieu (7 April 1971 – 13 October 2008) was a French actor, winner of a César Award, and the oldest child of Gérard Depardieu.
Depardieu was the son of actor Gérard Depardieu and his first wife, actress Élisabeth Depardieu (née Guignot). He was the brother of actress Julie Depardieu, and half-brother of Roxane and Jean Depardieu.
Guillaume shared the screen with his father several times throughout his career, beginning with his first film role, aged three, playing Gérard's son in Claude Goretta's That Wonderful Crook ("Pas Si Méchant Que Ça") in 1974. His next appearance beside his father was in Tous les matins du monde in 1993, followed by Count of Monte Cristo in 1998, and Aime Ton Père (titled "A Loving Father" in English) in 2002. In 1996 he won a César Award (France's national film award) as the most promising newcomer in Les Apprentis. In 2007, he began rebuilding his career with the films Don't Touch the Axe ("Ne Touchez Pas La Hache") and La France, and starred in the 2008 film De la guerre.