Francesco Acerbi (Italian pronunciation: ; born 10 February 1988) is an Italian professional footballer who plays as a central defender for Lazio in Serie A.
Until the age of 22, Acerbi played only in the lower tiers of the Italian football, before being purchased by the Serie B club Reggina, where he established himself as a starting lineup defender. In 2011, Acerbi signed with Chievo Verona, thus making his Serie A debut. Despite being used only sporadically, Acerbi managed to draw the attention of A.C. Milan, who signed him the next summer. Having appeared in 10 games for the rossoneri, Acerbi returned to Chievo to complete the season. In 2013, he signed with Sassuolo, where he would become an undisputed starter even in spite of his cancer diagnosis during his debut season for the club. In 2018, having made 173 appearances in all competitions for the neroverdi, Acerbi transferred to Lazio.