Daniele Padelli (born 25 October 1985) is an Italian professional footballer who plays as a goalkeeper for Serie A club Internazionale.
Padelli began his playing career at Delebio, a team from Valtellina of Seconda Categoria. He moved to Lecco in 2001 and then Como the year after. In 2004, he transferred to Sampdoria, playing for the primavera, before being loaned to Pizzighettone in Serie C1 (33 appearances with 29 goals conceded) and then Crotone (one appearance, 2 goals conceded).
On 12 January 2007, he was loaned to Liverpool for the duration of the season with the option to make the deal permanent. On the completion of the deal Liverpool manager Rafael Benítez said, "He's a good young goalkeeper who has been selected for his national side. Padelli will give us a good option for the future. The fact he is once again with the under-21s for his national side tells you that we are signing a very good player." He made his debut, and only appearance, for the club on 13 May 2007 against Charlton Athletic F.C. in the last league game of the 2006–07 season to become the first Italian to ever play for the club. However, his poor performance saw him concede two goals in a disappointing draw for the Reds. He returned to Sampdoria on 8 June 2007.