Carlos Manuel Hermosillo Goytortúa (born 24 August 1964 in Cerro Azul, Veracruz, Mexico) is a Mexican former football player. He is one of the top all-time goalscorers for the Mexico national team. He is also known as El Grandote de Cerro Azul (The big tall one from Cerro Azul). He currently works as an analyst for Telemundo Deportes.
Hermosillo started his club career with América during the 1983–84 season. He spent most of his club career in his native Mexico, also playing for Monterrey, Cruz Azul, Necaxa, Atlante, and Chivas. Carlos' best two seasons as a player were in 1994–95 and 1995–96, when he scored 35 and 36 goals respectively for Cruz Azul.
Hermosillo made two stints of career football outside Mexico: Belgium's Standard Liège in 1989–90 and Major League Soccer's Los Angeles Galaxy in 1998–99. For Galaxy, he scored 14 goals and 15 assists in two regular seasons, adding five goals and an assist in the playoffs.