Bob Wylie (born ()February 16, 1951) is an American football coach who is the current offensive line coach for the Ottawa Redblacks of the Canadian Football League (CFL). He served as the offensive line coach for the Oakland Raiders and the Cleveland Browns of the National Football League (NFL), both under head coach Hue Jackson. He held the same position for the Winnipeg Blue Bombers of the Canadian Football League.
On March 16, 2009, Wylie was named the offensive line coach of the Saskatchewan Roughriders. The Roughriders went 10–7 in 2009 and made the playoffs. They would go on to lose the 97th Grey Cup to the Montreal Alouettes 27–28. Under his coaching center Jeremy O'Day, and guard Gene Makowsky were named CFL All-Stars.
On January 22, 2010, Wylie was named an assistant offensive line coach for the Denver Broncos. The Broncos went 4–12 in 2010 and missed the playoffs. Head coach Josh McDaniels was fired during the season and Wylie was let go.