Angelo Palombo (Italian pronunciation: ; born 25 September 1981) is an Italian retired footballer who played as a midfielder. He has played in Serie A for Fiorentina, Sampdoria and Internazionale. Palombo won 22 caps for Italy at full international level, and represented his nation at the 2009 FIFA Confederations Cup and the 2010 FIFA World Cup, also winning a bronze medal at the 2004 Summer Olympics.
Born in Ferentino, Angelo Palombo began playing football for local side AS Ferentino. He spent the 1997–98 season with Serie D club Urbania Calcio. At age 17, he moved to Serie C team Fano before being signed by Serie A side Fiorentina in 1999 where he spent two years playing for the Primavera team of the club. He made his professional debut in a Coppa Italia match against Como and first featured in the Serie A on 10 February 2002 in a 2–0 away defeat against Venezia.
Palombo moved to Sampdoria, then in Serie B, on a free transfer in the 2002 summer transfer window when Fiorentina declared bankruptcy and were forced to put their players on sale. After helping the Ligurian club gain promotion that season, he established himself as an integral part of the side. During the 2005–06 season, he scored his first Serie A goal for Sampdoria on 18 January 2006 against his boyhood club Fiorentina and made his European debut in the UEFA Cup in September. Palombo had many very good seasons at the club, leading to him being a regular in the Italian national team. When Sampdoria were again relegated at the end of the 2010–11 season, his future at the club was put into doubt, with many Serie A sides interested but mainly his former club Fiorentina. Palombo, by then the club's captain, said, however, that he had no intention to move unless the club wished to sell him and remained at the club, commenting: "I'll end my career with Sampdoria. I'm proud to have received some important offers and I thank the clubs who have come forward. However, I haven't thought about leaving here, not even for a moment. I think I have already demonstrated how tied I am to this shirt."