Amanda Setton (born December 16, 1985) is an American actress. She is best known for her recurring role as Penelope Shafai on The CW's teen drama Gossip Girl (2008–12) and for her role as Kimberly Andrews on the ABC soap opera One Life to Live (2009–11). She made her Off-Broadway debut in the comedy play Love, Loss, and What I Wore in late 2011, and was on the first half of season one of the Fox comedy The Mindy Project.
Setton was born in New York City, and grew up in Great Neck, where she was president of her high school's theater club. She is Jewish, and of both Syrian-Jewish and Austrian-Jewish descent. Setton majored in drama at Ithaca College, where she graduated in 2007. In her junior year she studied abroad in Barcelona, Spain in an IES program. Setton completed a comprehensive two-year Meisner technique program at The Actor's Workshop of Ithaca under the instruction of Eliza VanCort.